Metformin is widely used to reduce the high blood sugar levels caused by diabetes. Recently, several studies have suggested that patients taking metformin who also develop cancer have tumors that grow more slowly than average. As clinical trials have already started to investigate if metformin is an effective anti-cancer treatment, it is important to understand how it might restrict tumor growth. Researchers have proposed two ways that metformin could affect tumors. First, insulin is known to prompt cancer cells to divide, so the slower rate of tumor growth could just be a side-effect of the metformin reducing the amount of insulin in the blood. Alternatively, metformin could target cancer cells more directly by cutting the energy supply produced by their mitochondria. Metformin has been shown to disrupt complex I of the electron transport chain that is used by cells to generate energy. If you are on a personal connection, like at home, you can run an anti-virus scan on your device to make sure it is not infected with malware. If you are at an office or shared network, you can ask the network administrator to run a scan across the network looking for misconfigured or infected devices. Another way to prevent getting this page in the future is to use Privacy Pass. Check out the browser extension in the Firefox Add-ons Store.
Metformin is commonly used to treat PCOS, or polycystic ovary syndrome. According to research posted to the Journal of Human Reproductive Sciences, women with PCOS, particularly those who are overweight, tend to be insulin resistant. PCOS can cause missed periods and infrequent ovulation. Metformin has been around for a long time. Metformin contains a substance called guanidine, which can lower blood sugars. Guanidine is found in an herb called goat’s rue also known as French lilac, and this herb has been used to treat diabetes since the early 1900s. The FDA approved metformin.