Clomid, also known as Serophene or clomiphene citrate (the generic name) is the most commonly prescribed fertility medication. Clomid is often used to help women ovulate who are not ovulating naturally or ovulate irregularly and want to get pregnant. It’s often part of treatment for women with PCOS, and may be used in women under 35 who have unexplained fertility. But what if you’ve used Clomid, and you’re not getting pregnant? In general, about three quarters of the women who were not ovulating regularly will ovulate with Clomid. However, about half the women who ovulate with Clomid do not get pregnant. What other treatments are available to help you get pregnant? Just because Clomid didn’t work for you, this doesn’t mean you can’t have a baby! If you're facing infertility, you have probably heard about a number of different medications that are commonly used to help couples conceive. Fertility specialist Mark Kan, MD, tells you about Clomid -- one of the first treatments your doctor may try. Mark Kan, MD Your question What is Clomid, and how does it work? The expert answers Clomiphene citrate (also known as Clomid or Serophene) is a medication that is commonly used in fertility treatment. Because it is relatively inexpensive and can be administered orally, clomiphene is generally one of the first medications prescribed for patients who do not ovulate regularly. In women who do ovulate regularly, clomiphene may be used for "superovulation," where 2 or 3 eggs are produced. This increases the number of "targets" for the sperm, thereby increasing the chance of pregnancy.
With the suspension of Cincinnati Reds pitcher Edinson Volquez for performance enhancing drug use and a swirl of rumors that the agent involved was clomiphene (also known as Clomid,) I thought it timely to write about how clomiphene works and how it’s used. From what I read on the internets, there is an enormous amount of misinformation floating around out there. To understand how clomiphene works, you need to know how the pituitary controls the making of testosterone in the testis. Testosterone is made by Leydig cells in the testis, which I explained in my last post. The pituitary releases a hormone called luteinizing hormone (“LH”) that stimulates the Leydig cells to make testosterone. Testosterone is converted to the female hormone estrogen, (which I also explained in my last post,) and estrogen tells the pituitary to stop making more LH. This kind of negative feedback system is common when it comes to how hormones work. As the room gets warmer, the thermostat sends less electricity to the heater. Clomid's primary purpose is to induce ovulation in women who are either not ovulating or ovulating irregularly. Between 70 and 80 percent of women taking Clomid will ovulate during their first treatment cycle. Your chances of getting pregnant over several cycles is approximately 35 percent. If you don't conceive after six months, it's time to move onto another treatment. Depending on which research studies you reference, the odds of conceiving during any one Clomid treatment cycle are between seven and 30 percent. The effectiveness of Clomid varies depending on the cause of infertility. Another study, this one from Scottland, looked at success rates for couples diagnosed with unexplained infertility. Couples were randomly assigned to one of three groups: "expectant management," treatment with just Clomid, or Clomid with IUI.
Jun 11, 2010. Clomid is probably the single most used fertility drug by OBGYNs across the United States. What is Clomid, does it *actually* work? What are the side effects? We explain all and how it could help you get pregnant.