Valacyclovir is used to treat infections caused by certain types of viruses. In children, it is used to treat cold sores around the mouth (caused by herpes simplex) and chickenpox (caused by varicella zoster). In adults, it is used to treat shingles (caused by herpes zoster) and cold sores around the mouth. The viruses that cause these infections continue to live in the body even between outbreaks. Valacyclovir is also used to treat outbreaks of genital herpes. Valacyclovir decreases the severity and length of these outbreaks. In people with frequent outbreaks, this medication is used to reduce the number of future episodes. It helps the sores heal faster, keeps new sores from forming, and decreases pain/itching. This medication may also help reduce how long pain remains after the sores heal. Read the Patient Information Leaflet if available from your pharmacist before you start taking valacyclovir and each time you get a refill. Kathryn Meininger began writing and publishing poetry in 1967. She was co-founder and editor of the professional magazine "Footsteps" and began writing articles online in 2010. She earned a Doctor of Podiatric Medicine from Temple University School of Podiatric Medicine and a Bachelor of Arts in biology from William Paterson University. View Full Profile Valtrex can affect kidney function, resulting in kidney failure. Valtrex, taken orally or intravenously, can lead to renal toxicity and renal failure in some who take the drug long term. According to the American Social Health Association, Valtrex converts to acyclovir as it is metabolized, and may crystallize out within the renal tubules, leading to renal toxicity and failure. Inadequate hydration can increase the chances for kidney failure, so drink plenty of water to keep your kidneys hydrated while taking Valtrex.
The dose in immunocompromised patients is 1000 mg three times daily for at least seven days (3000 mg total daily dose) and for 2 days following crusting of lesions. This dose should be reduced according to creatinine clearance (see Renal impairment below). For recurrent episodes, treatment should be for three to five days. For initial episodes, which can be more severe, treatment may have to be extended to ten days. For recurrent episodes of herpes simplex, this should ideally be during the prodromal period or immediately upon appearance of the first signs or symptoms. Valtrex can prevent lesion development when taken at the first signs and symptoms of an HSV recurrence. For herpes labialis (cold sores), valaciclovir 2000 mg twice daily for one day is effective treatment in adults and adolescents. The second dose should be taken about 12 h (no sooner than 6 h) after the first dose. Valacyclovir, a prodrug of acyclovir with greater oral bioavailability, has been widely used in recent years for the treatment of herpes virus infections. After its hepatic metabolism, it is eliminated through glomerular filtration and active tubular secretion. If toxicity is suspected, it is essential and early diagnosis and discontinuation of the medication. In selected cases, hemodialysis could accelerate the clearance of the drug and recovery from the toxic effects of the drug. An 87-year-old woman with no relevant past medical history, except hypertension and type 2 diabetes mellitus treated with metformin. She visited his primary care doctor for vesicular lesions along the path of the V1 branch of the left V cranial nerve. The patient was started on oral valacyclovir following the usual regimen (1h).
Acting as an oral prodrug, valacyclovir is converted in vivo to acyclovir. it may also increase the risk of renal toxicity due to precipitation of. Valtrex is indicated for the treatment of herpes zoster shingles and. Animal studies do not show reproductive toxicity for valaciclovir see section 5.3.