2 g orally every 12 hours for a total of 2 doses HIV-infected adult (guideline dosing): 1 g orally twice a day for 5 to 10 days Comments: -Therapy should be started at the earliest sign of a cold sore, e.g. -Efficacy of treatment when initiated after the development of clinical signs of a cold sore have not been established. -Guidelines for the Prevention and Treatment of Opportunistic Infections Among HIV- Infected Adults and Adolescents may be consulted for additional guidance. Use: For the treatment of cold sores (herpes labialis). Genital Herpes: FIRST EPISODE: 1 g orally twice a day Duration of therapy: 10 days (manufacturer): 7 to 10 days (CDC recommendation) RECURRENT EPISODES: 500 mg orally twice a day for 3 days OR 1 g orally once a day for 5 days -Therapy should be started at the first sign of a genital herpes episode Comments: -All patients with newly acquired genital herpes should receive antiviral therapy as first episodes can cause a prolonged clinical illness, even among persons with mild clinical manifestations initially. -Therapy for the initial episode is most effective when administered within 48 hours of onset of signs and symptoms; the efficacy or initiating treatment more than 72 hours after onset of signs and symptoms has not been established. -For recurrent episodes, the efficacy of starting more than 24 hours after onset of signs and symptoms has not been established. -CDC STD treatment Guidelines may be consulted for additional guidance. Valacyclovir works best if it is used within 48 hours after the first symptoms of shingles or genital herpes (e.g., pain, burning, or blisters) begin to appear. For recurrent outbreaks of genital herpes, valacyclovir works best if it is used within 24 hours after the symptoms begin to appear. If you are taking valacyclovir for the treatment of chickenpox, it is best to start taking valacyclovir as soon as possible after the first sign of the chickenpox rash appears, usually within one day. Valacyclovir may be taken with meals or on an empty stomach. If you are using the oral suspension, use a specially marked measuring spoon or other device to measure each dose accurately. The average household teaspoon may not hold the right amount of liquid. Drink extra fluids so you will pass more urine while you are using this medicine.
Genital herpes is prevalent and sometimes debilitating. Likewise, herpes zoster ('shingles') can be painful and often disabling. The treatment of these conditions has been advanced over the past two decades by the introduction of guanosine nucleoside antivirals such as valacyclovir (Valtrex), Glaxo Wellcome), the highly bioavailable prodrug of acyclovir (Zovirax), Glaxo Wellcome). This review describes the pharmacology, pharmacokinetics, clinical efficacy and tolerability of valacyclovir and considers its clinical attributes in the context of those of the antivirals, acyclovir and famciclovir (Famvir), Smith Kline Beecham). The data demonstrate that valacyclovir is more effective than placebo and as effective as other antivirals in the episodic and suppressive treatment of recurrent genital herpes. Valacyclovir is the only antiviral shown to be effective with a short (3-day) course in the episodic treatment of recurrent genital herpes, as well as with once-daily dosing for daily suppressive therapy. In herpes zoster, valacyclovir is as effective as famciclovir and more effective than either placebo or acyclovir at facilitating cutaneous healing and healing of zoster-associated pain and post-herpetic neuralgia. Valacyclovir is among the most common medications used to treat the infections caused by specific types of viruses. The medication is recommended to both children and adults. When given to children, it is used against the harsh effects of cold sores – mostly around the mouth. Children can also take Valacyclovir to treat chicken pox (caused by varicella zoster). When it comes to adults, the medication is most commonly given against oral cold sores, as well as shingles. Obviously, the treatment is individualized according to the patient’s age, infection, severity, symptoms and particular consideration – like other affections. Valacyclovir represents a common option against the recurring episodes of genital herpes as well. It is worth mentioning that the herpes infection can’t be curred yet. Once inside the body, it will remain there for the rest of your life.
Valacyclovir is used to treat HSV-1 and HSV-2, as well as the varicella zoster virus shingles, or VZV. Because of its antiviral properties, it's also used to prevent. Includes dosages for Herpes Simplex - Suppression, Herpes Simplex Labialis, Herpes Zoster and more; plus renal, liver and dialysis.