Sertraline belongs to a class of medications known as selective serotonin reuptake inhibitors (SSRIs). It is used to treat depression, panic disorder, and obsessive-compulsive disorder (OCD). Sertraline works by affecting the balance of chemicals in the brain. Specifically, it increases the level of a neurotransmitter called serotonin in the brain. Increased serotonin levels can help improve mood, reduce panic attacks, and treat OCD. Although improvements may occur earlier, the full response to the medication may not appear until after 4 weeks of treatment or longer. This medication may be available under multiple brand names and/or in several different forms. Forty-two adult female cynomolgus macaques consuming a Western diet were characterized during an 18-month pretreatment phase and assigned to SSRI (sertraline hydrochloride 20 mg/kg, per os, once a day) or placebo balanced on pretreatment . CAA, analyzed by a 2 (depressed, nondepressed) × 2 (placebo, sertraline) × 3 (coronary arteries) analysis of covariance adjusted for pretreatment iliac atherosclerosis, was greater in depressed than in nondepressed monkeys ( = .040). The observed CAA extent in depressed monkeys treated with sertraline was 4.9 times higher than that in untreated depressed monkeys, and 6.5 times higher than that in nondepressed monkeys, on average. From the Department of Pathology/Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina. Address correspondence and reprint requests to Carol A. Shively, Ph D, Department of Pathology/Comparative Medicine, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157-1040.
If you subscribe to any of our print newsletters and have never activated your online account, please activate your account below for online access. By activating your account, you will create a login and password. Do you worry about the effects of long-term use of antidepressants? These drugs are among the most commonly prescribed in the United States, and they're often prescribed for long-term use. But is it safe to use antidepressants for years on end? In spite of how popular these drugs are, we're just learning what those long-term effects may be. Extended studies are rarely done before a drug gains approval, so medications can be around for a long time before we start to get a clear picture of what can happen after years of continuous use. In your brain, information—including emotion—moves from one neuron (brain cell) to another via chemical messengers called neurotransmitters. Each one unlocks certain receptors (chemical "locks") on neurons in order to allow the message to keep traveling. In the diseases and conditions listed above, as well as many others, something is messed up with the neurotransmitters—usually serotonin and/or norepinephrine, and possibly dopamine and/or a few others. In some cases, the brain may not use it efficiently, or the problem could lie with the receptors.
Jul 15, 2012. In her bestselling 1997 memoir Prozac Nation, Elizabeth Wurtzel was already expressing concern about the long-term effects of her new. Oct 28, 2014. Be sure to visit your doctor regularly during the first 12 weeks that you are using Zoloft so that the medicine's effect on you can be monitored.